Modern history of spillovers

This chart shows the viral diseases that have spilled over from animals to humans since 1918, and how many people were killed by the resulting outbreaks. Spillover events have probably triggered every viral pandemic that’s occurred since the start of the twentieth century. The probability of future pandemics could be increasing, largely because of the way that people are changing the environment. The authors of a Comment article argue that the likelihood of spillover could be greatly reduced with investment to cut global deforestation in hotspots for emerging infectious diseases; curtail and regulate trade in wildlife; and improve the ability to detect and control infectious diseases in farmed animals. The cost of around US$20 billion per year, they say, is small compared with the lives lost and trillions of dollars spent in the current pandemic.

Infographic showing the increase in the number pandemic outbreaks and related deaths since 1910

Source: A. S. Bernstein et al. Sci. Adv. 8, eabl4183 (2022).

Destination Moon

More than 50 years since US astronauts last walked on the moon during the Apollo programme, NASA plans to send crews back to the lunar surface. This graphic shows the flight paths for the series of planned missions, called Artemis, after Apollo’s twin sister in Greek mythology. The first mission, Artemis 1, will fly around the Moon this year. The crew will make use of the Space Launch System — the most powerful rocket ever built and nearly 100 metres tall. This and other fantastic graphics illustrate the US$93-billion plan to put astronauts back on the Moon.

Three diagrams showing the details of the three Artemis missions.

Drugs taking the fast route

This graphic illustrates how many treatments are being approved by the US Food and Drug Administration’s accelerated-approval programme. The FDA created the fast-track pathway in 1992 to get urgently needed drugs to the market without delay. Instead of demonstrating efficacy through clinically meaningful endpoints, such as patient survival or reduction of symptoms, drug candidates reviewed under this pathway often rely on what are known as surrogate endpoints, which may be faster or easier to track. For example, tumour shrinkage is a common surrogate used in clinical trials of cancer drugs, but this metric does not necessarily translate into meaningful benefits for patients. Our News story explains some researchers’ concerns that the process is being used too often by the pharmaceutical industry to speed approvals.

Growing momentum for accelerated approval: Bar chart showing treatments accepted through accelerated approval 1992 to 2001.

Source: FDA

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